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Vasogen Announces Second Quarter 2006 Results

Toronto, Ontario - July 12, 2006

Vasogen Inc. (NASDAQ:VSGN; TSX:VAS) today reported the results of operations for the second quarter of 2006. Comparative figures relate to the three- and six-month periods ended May 31, 2006, and to the three- and six-month periods ended May 31, 2005. All dollar amounts referenced herein are in Canadian dollars, unless otherwise stated.

At May 31, 2006, our cash and cash equivalents, restricted cash, and marketable securities held to maturity totaled $42.5 million, compared with $85.2 million at November 30, 2005.

The loss for the second quarter of 2006 was $22.4 million, or $0.26 per share, compared to a loss of $25.1 million, or $0.31 per share, in the second quarter of 2005. For the six months ended May 31, 2006, the loss was $41.8 million, or $0.49 per share, compared to a loss of $45.0 million, or $0.57 per share, for the comparable period in 2005. The loss has decreased as a result of a reduction in the costs associated with our phase III clinical programs and has been partially offset by expenses associated with the senior convertible notes. The difference between cash used in operations and our accounting loss includes such non-cash items as stock option grant expense, amortization expense, accretion and amortization of costs associated with the senior convertible notes payable, offset by payment of accrued expenses related to our phase III clinical trials.

Research and development expenditures were $11.0 million in the second quarter of 2006, compared to $20.7 million in the second quarter of 2005. For the six months ended May 31, 2006, these expenditures were $22.4 million, compared to $37.5 million for the comparable period in 2005. The majority of the decrease in our R&D expense for the three months and six months ended May 31, 2006, when compared with the same periods in 2005, resulted from a significant reduction in the clinical trial activities relating to our phase III programs.

General and administration expenditures were $5.6 million for the second quarter of 2006, compared to $6.0 million for the second quarter of 2005. For the six months ended May 31, 2006, these expenditures were $10.5 million, compared to $11.4 million for the comparable period in 2005.

An expanded Management's Discussion and Analysis for the quarter is accessible on Vasogen's web site at www.vasogen.com.

Highlights

• On June 26, 2006 we announced the initial results from the 2,414-patient phase III ACCLAIM trial of Celacade™ technology in advanced chronic heart failure. While the ACCLAIM study did not reach the primary endpoint of significantly reducing the risk of death and cardiovascular hospitalization in the total patient population, this endpoint was met for a large pre-specified subgroup of 692 patients with New York Heart Association (NYHA) Class II chronic heart failure. In the study, NYHA Class II heart failure patients receiving Celacade therapy had a 39.1% reduction (p=0.0003) in their risk of death and cardiovascular hospitalization, compared to placebo. The Class II heart failure patients comprised 29% of the trial's total population and experienced 26%, or 216 primary endpoint events, indicating a similar event risk profile to the NYHA Class III & IV patients in the study.
  
  
• We are continuing our analysis of the ACCLAIM data and we expect additional findings to be presented at the World Congress of Cardiology (WCC) 2006, being held from September 2 to 6 in Barcelona, Spain, and at the 10th Annual Scientific Meeting of the Heart Failure Society of America (HFSA) being held in Seattle, Washington, from September 10 to 13, 2006. The WCC 2006 brings together the XVth World Congress of Cardiology of the World Heart Federation and the 2006 Congress of the European Society of Cardiology and is the largest medical meeting in Europe. The Annual Scientific Meeting of the HFSA is the largest meeting in North America of scientists and healthcare professionals devoted to heart failure research.
  
  
• On May 2, 2006, we announced that preclinical findings from our VP025 drug development program demonstrated a significant reduction of several pro-inflammatory cytokines in a preclinical model of diabetes and diabetic retinopathy, a common complication of diabetes that eventually results in the loss of vision. Dr. Kyle Krady, Assistant Professor of Neural and Behavioral Sciences, Penn State College of Medicine, presented the findings on May 1 at the Scientific Sessions of the Association for Research in Vision and Ophthalmology (ARVO) Annual Meeting in Florida.

As previously announced, a conference call and audio web cast will be conducted on July 12, 2006, at 4:30 p.m. Eastern Time. The conference call may be accessed by calling 416-695-9753 or 1-888-789-0150, ten minutes prior to the call. An audio webcast of the event will also be available at www.vasogen.com. A re-broadcast of the conference call may be accessed by calling 416-695-6030 or 1-866-578-1010 - pin code: 7109, and will also be available at www.vasogen.com.

About Vasogen
Vasogen is focused on the research and commercial development of technologies targeting the chronic inflammation underlying cardiovascular and neurological disease. The recently completed international 2,400-patient ACCLAIM trial assessed the impact of the Celacade technology on reducing the risk of mortality and morbidity in patients with advanced heart failure. Full results for the ACCLAIM study are scheduled to be presented at the World Congress of Cardiology 2006, being held from September 2 to 6 in Barcelona, Spain, and at the 10th Annual Scientific Meeting of the Heart Failure Society of America being held in Seattle, Washington, from September 10 to 13, 2006. Vasogen is also developing a new class of drugs for the treatment of neuro-inflammatory and neuro-vascular disorders. VP025, which is entering phase II clinical development, is the lead product candidate from this new class of drugs.

Certain statements contained in this press release and upcoming conference call and web cast constitute "forward-looking statements" within the meaning of the United States Private Securities Litigation Reform Act of 1995. These statements include, without limitation, summary statements relating to initial results of the ACCLAIM trial in patients with chronic heart failure, plans to advance the development of Celacade, statements concerning our partnering activities, strategy, future operations, future financial position, future revenues, projected costs, prospects, plans and objectives of management. Except for results on the primary endpoint, initial results disclosed are based on initial data analyzed and may not be confirmed upon full analysis of the detailed results of the ACCLAIM trial and additional information relating to safety and efficacy of Celacade may be discovered upon further analysis of trial data and upon further review and analysis of additional trial data. In some cases, you can identify forward-looking statements by terminology such as "may", "will", "should", "expects", "plans", "anticipates", "believes", "estimated", "predicts", "potential", "continue", "intends", "could", or the negative of such terms or other comparable terminology. You should not place undue reliance on our forward-looking statements which are subject to a multitude of risks and uncertainties that could cause actual results, future circumstances or events to differ materially from those projected in the forward-looking statements. These risks include, but are not limited to, the outcome of further analysis of the ACCLAIM trial results, the requirement or election to conduct additional clinical trials, risks associated with the outcome of our research and development programs, the adequacy, timing and results of our clinical trials, the need for additional capital and the effect of capital market conditions and other factors on capital availability, the potential dilutive effects of any financing, including the convertible notes we issued in October 2005, the regulatory approval process, competition, securing and maintaining corporate alliances, market acceptance of our products, the availability of government and insurance reimbursements for our products, the strength of intellectual property, reliance on subcontractors and key personnel, losses due to fluctuations in the U.S.-Canadian exchange rate, and other risks detailed from time to time in our public disclosure documents or other filings with the Canadian and U.S. securities commissions or other securities regulatory bodies. Additional risks and uncertainties relating to our Company and our business can be found in the "Risk Factors" section of our Annual Information Form and Form 40F for the year ended November 30, 2005 as well as in our later public filings. The forward-looking statements are made as of the date hereof, and we disclaim any intention and have no obligation or responsibility, except as required by law, to update or revise any forward-looking statements, whether as a result of new information, future events or otherwise. Unless otherwise indicated, numerical values indicating the statistical significance ("p-values") of results included in this document are based on analyses that do not account for endpoint multiplicity.

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